Interleukin-6 Gene Polymorphisms Influencing in hematological indices from sickle cell Anemia Patients

The homozygous hemoglobin SS is characterized Sickle Cell Anemia (SCA), altering the original structure of erythrocytes to a sickle shape. hemoglobinopathies encompass all genetic diseases and SCA one that presents greatest clinical manifestations variability also most severe ones, causing chronic hemolysis, vaso-occlusive crises anemia in patients. present study aimed investigate role rs2069832, rs2069835, rs2069840, rs2069845 rs2069849 polymorphisms Interleukin-6 gene hematological values patients treated at Fundação HEMOAM, Manaus, AM. inclusion was carried out through outpatient care HEMOAM. Genomic DNA extracted using QIAamp Mini Kit (Qiagen) molecular analyzes by TaqMan® probes on Applied Biosystems QuantStudio 6 Flex Real-Time PCR System. A total 277 were included this study, having female gender minimally higher frequency (55.3%). mean age diagnosis approximately three years old, with brown race being predominant (77.6%). rs2069832_AA rs2069845_AA genotypes showed high for red blood cell, hematocrit indices, an important as protective factor hemolysis these While rs2069835_CC genotype decreased same hematimetric demonstrating be potential risk increased hemolysis. No significant correlation indices observed rs2069840 genotypes. There are few studies correlating variants IL-6 state Amazonas, however, it known involved cell proliferation greater response inflammatory cytokines, may modulate patients, such vaso-occlusion infections. Our work demonstrated associations possible anemia. We understand investigation larger number would recommended elucidate roles studied In addition, elucidating Il-6 lead development new strategies therapies prevent systemic effects excessive cytokine production and, consequently, reduce severity providing better prognosis, follow-up welfare.